Lyng Pharmacy
Medicines A–Z · Antiplatelet

Clopidogrel

An antiplatelet medicine · Written by the Lyng Pharmacy team, based on NHS and BNF guidance · Updated August 2026
Also sold asPlavix
Type of medicineAntiplatelet
Available asTablets
How you get itPrescription only

Clopidogrel makes platelets less sticky, reducing the chance of a clot forming in an artery. It is prescribed after heart attacks, strokes and stents, and stopping it without advice — particularly soon after a stent — can be genuinely dangerous.

What it is used for

Preventing clots after a heart attack, stroke or transient ischaemic attack, in peripheral arterial disease, and after coronary stents — often alongside aspirin for a defined period.

How to take it

Once daily, at the same time each day, with or without food.

Do not stop clopidogrel without medical advice, especially in the months after a stent, when stopping early substantially increases the risk of a clot. Tell your dentist and any surgeon that you take it rather than stopping on your own.

If you miss a dose, take it the same day if you remember. Skip it if it is nearly time for the next — never double up.

Bleeding and interactions

Bruising more easily, nosebleeds and cuts taking longer to stop are expected. Report bleeding that will not stop, blood in urine, black tarry stools, coughing or vomiting blood, or any head injury.

Call 999 for severe bleeding, a serious head injury, or sudden severe headache with confusion or weakness.

Omeprazole and esomeprazole can reduce how well clopidogrel works. If you need stomach protection, lansoprazole or pantoprazole is usually preferred — tell us if you buy any acid medicine over the counter.

Also tell your prescriber about anti-inflammatories, aspirin, anticoagulants and SSRIs, all of which add bleeding risk.

Always read the label. This page is general information, not advice for your situation. Doses, warnings and interactions differ between products and between people. Check the leaflet inside your medicine, and ask our pharmacist if anything is unclear — that conversation is free and takes two minutes.

Questions about Clopidogrel?

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Frequently asked questions

Can I stop clopidogrel before dental work?
Not without advice. Tell your dentist you take it — stopping without medical guidance, particularly after a stent, can be dangerous.
Can I take omeprazole with clopidogrel?
Omeprazole and esomeprazole can reduce clopidogrel’s effect. Lansoprazole or pantoprazole is usually preferred — check with us before buying acid medicines.
Is bruising normal on clopidogrel?
Easier bruising and longer bleeding from cuts are expected. Bleeding that will not stop, black stools or blood in urine need prompt attention.
Can I take ibuprofen with clopidogrel?
Check with us first — it adds bleeding risk. Paracetamol is usually the safer painkiller.

Related pages

Aspirin →Lansoprazole →Atorvastatin →All medicines A–Z →

More from Lyng Pharmacy

Order a repeat prescription →Pharmacy First — NHS treatment without a GP →Free medicine review →Contact us & opening hours →
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