Edoxaban is a once-daily direct oral anticoagulant. Like apixaban and rivaroxaban it needs no INR testing, and like them it wears off within hours — so missing doses leaves you unprotected far sooner than with warfarin.
Reducing stroke risk in atrial fibrillation, and treating and preventing deep vein thrombosis and pulmonary embolism.
It is not suitable for people with mechanical heart valves. The dose is reduced for low body weight, reduced kidney function, or certain interacting medicines.
Once daily at the same time, with or without food. Swallow whole with water.
If you miss a dose, take it the same day as soon as you remember, then continue as normal. Never take two doses in one day.
Kidney function is checked periodically, since the dose depends partly on it. Edoxaban is less effective in people with unusually good kidney function in atrial fibrillation, which your prescriber will have considered.
Contact your doctor promptly for bleeding that will not stop, unusually heavy periods, blood in urine, black tarry stools, coughing or vomiting blood, unexplained widespread bruising, or any head injury.
Call 999 for severe bleeding, a serious head injury, or sudden severe headache with confusion or weakness.
Carry your anticoagulant alert card and tell any healthcare professional, including your dentist, before any procedure.
Check with us before taking anything new, including over-the-counter and herbal products. Ibuprofen, aspirin, St John’s wort, some antifungals and rifampicin all matter.
Not used in pregnancy — speak to your GP if you are pregnant or planning to be.
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