Hydroxychloroquine is used in rheumatoid arthritis, lupus and some other autoimmune conditions. It is among the better tolerated DMARDs, and it needs one thing most others do not: regular eye screening.
Usually once or twice daily with or after food, which reduces nausea.
It works slowly — allow three to six months before judging the benefit. Do not stop early because nothing seems to be happening.
Take it consistently; it is a long-term medicine, often taken for years.
Risk is higher at higher doses relative to body weight, with kidney impairment, with long duration of use, and alongside tamoxifen.
Nausea, stomach upset, headache, rash and, less often, hair lightening are the common effects.
Report a rash, particularly a widespread or blistering one, unusual bruising or bleeding, muscle weakness, or symptoms of low blood sugar such as sweating and shakiness.
Tell your prescriber if you have psoriasis, which it can worsen, or G6PD deficiency, and about medicines that affect heart rhythm, digoxin, insulin and diabetes tablets.
It is generally considered acceptable to continue in pregnancy and breastfeeding where needed — discuss with your specialist rather than stopping on your own.
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