Lyng Pharmacy
Medicines A–Z · Thiazide-like diuretic

Indapamide

A thiazide-like diuretic · Written by the Lyng Pharmacy team, based on NHS and BNF guidance · Updated August 2026
Also sold asNatrilix SR
Type of medicineThiazide-like diuretic
Available asTablets, modified-release tablets
How you get itPrescription only

Indapamide is a thiazide-like diuretic used mainly for high blood pressure. It is milder than furosemide and taken for the blood pressure benefit rather than to shift fluid, but it still affects the salts in your blood, which is why the blood tests matter.

How to take it

Once daily in the morning, with or without food. Modified-release tablets are swallowed whole.

Morning dosing matters — taken later it will have you up in the night.

It can take several weeks to reach its full blood-pressure-lowering effect. Do not stop because readings have normalised.

Blood tests and salts

Kidney function, sodium and potassium are checked before starting and periodically after. Low sodium and low potassium are the main things being looked for.

Report muscle cramps or weakness, unusual tiredness, confusion, an irregular heartbeat, or marked thirst with a dry mouth — these can indicate a salt imbalance.

Pause it during dehydrating illness — vomiting, diarrhoea, fever with heavy sweating — and ask for a sick day rules card.

Other points

Common side effects: dizziness on standing, headache, and increased urination early on.

Diuretics can trigger or worsen gout, and can raise blood sugar slightly.

Tell your prescriber about lithium, digoxin, anti-inflammatories such as ibuprofen, and other blood pressure medicines.

It also increases sun sensitivity in some people — use sun protection.

Always read the label. This page is general information, not advice for your situation. Doses, warnings and interactions differ between products and between people. Check the leaflet inside your medicine, and ask our pharmacist if anything is unclear — that conversation is free and takes two minutes.

Questions about Indapamide?

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Frequently asked questions

When should I take indapamide?
Once daily in the morning. Later doses will have you getting up in the night.
Why do I need blood tests on indapamide?
It affects sodium, potassium and kidney function, all of which are checked before starting and periodically after.
Should I stop indapamide when I am ill?
Pause it during dehydrating illness such as vomiting, diarrhoea or fever, and ask us for a sick day rules card.
Can indapamide cause gout?
Diuretics can trigger or worsen gout. Tell your GP if you develop a hot, painful joint.

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