Linagliptin works the same way as sitagliptin, with one practical difference that matters a lot in general practice: it is cleared mainly through the gut rather than the kidneys, so it usually needs no dose adjustment in kidney impairment. That is often why it is the gliptin chosen.
One 5mg tablet once daily, with or without food, at the same time each day. Swallow whole.
It can be taken alone or alongside metformin, a sulfonylurea, an SGLT2 inhibitor or insulin.
If you miss a dose, take it when you remember unless the next is nearly due — never double up.
Unlike most other diabetes tablets, linagliptin does not usually need its dose reducing when kidney function is impaired, because it is largely eliminated through the bowel. That makes it a common choice in older patients and in chronic kidney disease.
Your kidney function will still be monitored as part of routine diabetes care.
Generally very well tolerated. Cold-like symptoms, cough, and raised pancreatic enzymes are among the reported effects.
Also report blistering of the skin, severe joint pain, or swelling of the face, lips or throat.
Hypos are unlikely with linagliptin alone but possible when combined with a sulfonylurea or insulin.
It is not used in pregnancy — tell your diabetes team if you are planning one.
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