Quetiapine is used in schizophrenia, bipolar disorder and, at lower doses, as an add-on in depression and anxiety. It is more sedating than most antipsychotics, which is sometimes the point and sometimes the problem.
Standard tablets are usually taken twice daily; modified-release once daily, swallowed whole and taken without food or with a light meal.
The dose is built up gradually, which reduces dizziness and drowsiness. Take it at the same times each day.
Do not stop quetiapine suddenly. Abrupt withdrawal can cause nausea, insomnia, headache and a return of symptoms. Any reduction should be gradual and planned with your prescriber.
Drowsiness, dizziness on standing, dry mouth, constipation, weight gain and increased appetite are the common ones. Sedation often eases over a few weeks.
Do not drive until you know how it affects you.
Contact your doctor for:
Antipsychotics affect weight, blood sugar and cholesterol. You should have weight, blood pressure, glucose or HbA1c and lipids checked before starting, at three months, and then at least annually. If nobody has offered this, ask — it is easy for it to slip.
Alcohol adds substantially to sedation. Tell your prescriber about other sedating medicines, and about medicines that affect heart rhythm.
Discuss pregnancy plans with your prescriber rather than stopping on your own.
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