Lyng Pharmacy
Medicines A–Z · Non-drowsy antihistamine

Loratadine

Also sold as Clarityn · Written by the Lyng Pharmacy team, based on NHS and BNF guidance · Updated August 2026
Also sold asClarityn
Type of medicineNon-drowsy antihistamine
Available asTablets, liquid
How you get itGeneral sale and pharmacy

Loratadine is a once-daily non-drowsy antihistamine, and the one least likely of the common three to make you sleepy. It is also the one with the most reassuring safety record in pregnancy, which is why it tends to be recommended first there.

What it is used for

Hay fever and allergic rhinitis, allergic conjunctivitis, hives, and itching from allergic reactions including insect bites and stings.

Like other antihistamines, it does far more for sneezing, itching and a runny nose than for congestion. A blocked nose needs a steroid nasal spray.

How to take it

Adults and children over 12 take 10mg once daily. Children aged 2 to 12 take a lower dose based on weight — follow the label or ask us.

Take it with or without food, at the same time each day. It usually starts working within one to three hours and lasts a full 24 hours.

For seasonal hay fever, daily use through the season is more effective than as-needed dosing.

Side effects

Loratadine is well tolerated. Headache, tiredness, dry mouth and nausea are the most commonly reported, and are usually mild.

Drowsiness is uncommon but not impossible — if it affects you, do not drive or operate machinery.

Get medical help for swelling of the face, lips or throat, difficulty breathing, or a severe rash.

Who should take care

People with liver problems may need a reduced dose or less frequent dosing. Anyone with severe kidney problems should check first.

Loratadine is generally the preferred antihistamine in pregnancy where one is needed, and can be used while breastfeeding. As with other antihistamines, stop it several days before allergy skin-prick testing.

Always read the label. This page is general information, not advice for your situation. Doses, warnings and interactions differ between products and between people. Check the leaflet inside your medicine, and ask our pharmacist if anything is unclear — that conversation is free and takes two minutes.

Questions about Loratadine?

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Frequently asked questions

Is loratadine non-drowsy?
Yes, and it is the least likely of the common antihistamines to cause drowsiness. A small number of people still feel sleepy on it.
Can I take loratadine in pregnancy?
Loratadine is generally the preferred antihistamine in pregnancy where one is needed. Check with your midwife or our pharmacist first.
How long does loratadine take to work?
Usually one to three hours, with the effect lasting a full 24 hours.
Can I take loratadine with cetirizine?
No — do not take two antihistamines together. If one is not working, switch rather than combine, and ask us if you are unsure.

Related pages

Cetirizine →Fexofenadine →Hay fever →All medicines A–Z →

More from Lyng Pharmacy

Order a repeat prescription →Pharmacy First — NHS treatment without a GP →Free medicine review →Contact us & opening hours →
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